- ScanMaker i800 Plus
- ScanMaker s450
- ScanMaker s460
- ScanMaker s480
- ScanSoft
- Scantlin Electronics
- Scantron
- Scarab Research Inc.
- SCC (Specialist Computer Centres)
- SCELBI
- SCELBI-8H
- Scepter Technologies,Inc.
- Sceptre X226W-1920
- Sceptre E246W-1080P
- Sceptre Incorporated
- Sceptre X195W-NAGA
- Sceptre X23WG-1080P
- Sceptre X240T-1920
- Sceptre X24WG-1080P
- Sceptre X270W-1080P
- Sceptrre X246W-1080P
- Schell Games
- Schickard’s calculating clock
- Schlumberger
- Schogini Systems Private Ltd.
- School Management Software
- SchoolNet
- Schrodinger
- SCHWARZ Computer Systeme GmbH
- SciBit
- Science Fiction, Science Fact, and the Future of Computing
- Science Museum - London
- Scientific Atlanta
- Scientific Computer Applications
- Scientific Data Systems (SDS)
- Scientigo
- Scintilla Software Technology Ltd
- SciQuest
- SciSys ltd
- SciTech Software AB
- Scitor Corporation
- Scivantage
- SCM Data
- SCO Group, The
- SCO OpenServer
- Scopely
- Score Information Technologies Ltd
- Scott Adams
- Scott Adams
- Scott Adams
- Scott Adams
- Scott Adams ("Dogbert")
- Scott Cook
- Scott McNealy
- Scott McNealy
- Scott McNealy
- Scott McNealy
- Scott W. Ambler
- Screaming Bee
- ScreenHunter Free
- Screensaver Maker
- Scripped
- Scripped, Inc
- Scripsit
- ScriptLogic
- ScriptRock Inc
- ScriptSwitch Limited
- SCS Software
- SCSK Corporation
- Sculptris
- SDC3012N
- SDGblue, LLC
- SDL
- SDLC Partners
- SDRC
- Seagate Software
- Seagate STBF500300
- Seagate STBU1000300
- Seagate STBU1000301
- Seagate STBU1000302
- Seagate STBU1000303
- Seagate STBU500300
- Seagate STBU500301
- Seagate STBU500302
- Seagate STBU500303
- Seagate STBU750300
- Seamgen
- SeaMonkey
- Sean Parker
- Searce
- Search and Recover
- Search Technologies
- Search Truth Technologies
- Searchdaimon As
- SearchFox
- Sears
- Sears Gunslinger II
- Sears Tele-Games 80007
- Sears Tele-Games Hockey-Jokari