- Sierra Aces of the Deep
- Sierra Caesar 3
- Sierra Gabriel Knight 3
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- Sierra Gobliins 2
- Sierra Goblins Quest 3
- Sierra Half-Life
- Sierra Half-Life Opposing Force
- Sierra Hellfire
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- Sierra Lords of Magic
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- SigmaPlot
- SigmaTel High Definition Audio CODEC
- Sketcher
- Skype
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- Skype Portable
- SkypeLauncher
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- SlimComputer
- SlimDrivers Free
- Smart Defrag
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- SmartMarine 3D
- SmartPlant Foundation
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- Solid YouTube Downloader and Converter
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- SolSuite Solitaire 2012
- Sony Ericsson PC Suite
- SopCast
- Sound Forge
- SoundMAX Integrated Digital Audio
- SpeedFan
- SpinRite
- Spring Cleaning Deluxe
- Sprint
- Spybot - Search & Destroy
- SpywareGuard
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- SQLite
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- Star Downloader Free
- StarCraft Brood War
- StarOffice
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- STRETCH Assembly Program
- StuffIt - Mac
- StuffIt - Windows
- StuffIt Deluxe - Mac
- StuffIt Deluxe - Windows
- Sunbird
- Super Asterisk Password Viewer
- Super Mario 3: Mario Forever
- SuperAntiSpyware Free Edition
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- Symantec Q&A
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